In vivo matrix metalloproteinase-7 substrates identified in the left ventricle post-myocardial infarction using proteomics.

@article{Chiao2010InVM,
  title={In vivo matrix metalloproteinase-7 substrates identified in the left ventricle post-myocardial infarction using proteomics.},
  author={Ying Ann Chiao and Rogelio Zamilpa and Elizabeth F. Lopez and Qiuxia Dai and Gladys Patricia Escobar and Kevin W. Hakala and Susan T. Weintraub and Merry L Lindsey},
  journal={Journal of proteome research},
  year={2010},
  volume={9 5},
  pages={2649-57}
}
Matrix metalloproteinase-7 (MMP-7) deletion has been shown to improve survival after myocardial infarction (MI). MMP-7 has a large array of in vitro substrates, but in vivo substrates for MMP-7 following MI have not been fully identified. Accordingly, we evaluated the infarct regions of wild-type (WT; n = 12) and MMP-7 null (null; n = 10) mice using a proteomic strategy. Seven days post-MI, infarct regions of the left ventricles were excised, homogenized, and protein extracts were analyzed by… CONTINUE READING

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