In vivo matrix-guided human mesenchymal stem cells

  title={In vivo matrix-guided human mesenchymal stem cells},
  author={Jan Kramer and Florian B{\"o}hrnsen and Ulrich Lindner and Peter Behrens and Peter Schlenke and J{\"u}rgen Rohwedel},
  journal={Cellular and Molecular Life Sciences},
Microfracture of subchondral bone results in intrinsic repair of cartilage defects. Stem or progenitor cells from bone marrow have been proposed to be involved in this regenerative process. Here, we demonstrate for the first time that mesenchymal stem (MS) cells can in fact be recovered from matrix material saturated with cells from bone marrow after microfracture. This also introduces a new technique for MS cell isolation during arthroscopic treatment. MS cells were phenotyped using specific… CONTINUE READING

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