In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer’s disease

@article{Kuhl1999InVM,
  title={In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer’s disease},
  author={David Kuhl and Robert A. Koeppe and Satoshi Minoshima and Scott Snyder and E Ficaro and Normal L. Foster and Kirk A. Frey and Michael R. Kilbourn},
  journal={Neurology},
  year={1999},
  volume={52},
  pages={691 - 691}
}
Objective: To validate an in vivo method for mapping acetylcholinesterase (AChE) activity in human brain, preparatory to monitoring inhibitor therapy in AD. Background: AChE activity is decreased in postmortem AD brain. Lacking a reliable in vivo measure, little is known about central activity in early AD, when the disease is commonly targeted by AChE inhibitor drug therapy. Methods: Intravenous N-[11C]methylpiperidin-4-yl propionate ([11C]PMP) served as an in vivo AChE substrate. AChE activity… 

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