In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer’s disease

  title={In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer’s disease},
  author={D. Kuhl and R. Koeppe and S. Minoshima and S. Snyder and E. Ficaro and N. Foster and K. Frey and M. Kilbourn},
  pages={691 - 691}
  • D. Kuhl, R. Koeppe, +5 authors M. Kilbourn
  • Published 1999
  • Medicine
  • Neurology
  • Objective: To validate an in vivo method for mapping acetylcholinesterase (AChE) activity in human brain, preparatory to monitoring inhibitor therapy in AD. Background: AChE activity is decreased in postmortem AD brain. Lacking a reliable in vivo measure, little is known about central activity in early AD, when the disease is commonly targeted by AChE inhibitor drug therapy. Methods: Intravenous N-[11C]methylpiperidin-4-yl propionate ([11C]PMP) served as an in vivo AChE substrate. AChE activity… CONTINUE READING
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