In vivo manipulation of gene expression in non-human primates using lentiviral vectors as delivery vehicles.

@article{Dissen2009InVM,
  title={In vivo manipulation of gene expression in non-human primates using lentiviral vectors as delivery vehicles.},
  author={Gregory A. Dissen and Alejandro Lomniczi and Tanaya L Neff and Theodore R. Hobbs and Steven G. Kohama and Christopher D. Kroenke and Francesco Galimi and Sergio R. Ojeda},
  journal={Methods},
  year={2009},
  volume={49 1},
  pages={70-7}
}
Non-human primates (NHPs) are an invaluable resource for the study of genetic regulation of disease mechanisms. The main disadvantage of using NHPs as a preclinical model of human disease is the difficulty of manipulating the monkey genome using conventional gene modifying strategies. Lentiviruses offer the possibility of circumventing this difficulty because they can infect and transduce either dividing or nondividing cells, without producing an immune response. In addition, lentiviruses can… CONTINUE READING

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