In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.

@article{Meraviglia2010InVM,
  title={In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.},
  author={Serena Meraviglia and Matthias Eberl and David Vermijlen and Matilde Todaro and Simona Buccheri and Giuseppe Cicero and Carmela La Mendola and Giuliana Guggino and Matilde D'Asaro and Valentina Orlando and Filippo Scarpa and Alice Roberts and Nadia Caccamo and Giorgio Stassi and Francesco Dieli and Adrian C. Hayday},
  journal={Clinical and experimental immunology},
  year={2010},
  volume={161 2},
  pages={290-7}
}
The potent anti-tumour activities of gammadelta T cells have prompted the development of protocols in which gammadelta-agonists are administered to cancer patients. Encouraging results from small Phase I trials have fuelled efforts to characterize more clearly the application of this approach to unmet clinical needs such as metastatic carcinoma. To examine this approach in breast cancer, a Phase I trial was conducted in which zoledronate, a Vgamma9Vdelta2 T cell agonist, plus low-dose… CONTINUE READING
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