In vivo lung lavage as an experimental model of the respiratory distress syndrome.

Abstract

Using adult guinea-pigs, we have developed an experimental model in which alveolar surfactant phospholipids are removed by repeated lung lavage in vivo, and in which the short-term survival of the animals is ensured by artificial ventilation. Blood gases, parameters of lung mechanics, and histologic and electron microscopic findings indicate that the lavage… (More)

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@article{Lachmann1980InVL, title={In vivo lung lavage as an experimental model of the respiratory distress syndrome.}, author={Bernd Lachmann and B. Robertson and Jason R. Vogel}, journal={Acta anaesthesiologica Scandinavica}, year={1980}, volume={24 3}, pages={231-6} }