In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer.

@article{Kodama2017InVL,
  title={In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer.},
  author={Michiko Kodama and Takahiro Kodama and Justin Newberg and Hiroyuki Katayama and Makoto Kobayashi and Samir M Hanash and Kosuke Yoshihara and Zhubo Wei and Jean C-Y Tien and Roberto Rangel and Kae Hashimoto and Seiji Mabuchi and Kenjiro Sawada and Tadashi Kimura and Neal G. Copeland and Nancy A. Jenkins},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 35},
  pages={
          E7301-E7310
        }
}
Epithelial ovarian cancer (EOC) is a deadly cancer, and its prognosis has not been changed significantly during several decades. To seek new therapeutic targets for EOC, we performed an in vivo dropout screen in human tumor xenografts using a pooled shRNA library targeting thousands of druggable genes. Then, in follow-up studies, we performed a second screen using a genome-wide CRISPR/Cas9 library. These screens identified 10 high-confidence drug targets that included well-known oncogenes such… CONTINUE READING
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