In vivo location of the rate-limiting step of hexose uptake in muscle and brain tissue of rats.

@article{Furler1991InVL,
  title={In vivo location of the rate-limiting step of hexose uptake in muscle and brain tissue of rats.},
  author={Stuart M Furler and Arthur B. Jenkins and Len H. Storlien and Edward W. Kraegen},
  journal={The American journal of physiology},
  year={1991},
  volume={261 3 Pt 1},
  pages={E337-47}
}
The uptake of glucose proceeds via facilitated transport from the plasma followed by phosphorylation of intracellular glucose. We have quantified the relative contribution of transport and phosphorylation to the overall rate of hexose utilization into the quadriceps muscle (red and white) and cerebellum of rats anesthetized with pentobarbital sodium. The method employed simultaneous infusions of radiolabeled 3-O-methyl-D-glucose and 2-deoxy-D-glucose. Results were expressed in terms of a… CONTINUE READING

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