In vivo lipid peroxidation in rat brain following intracortical Fe2+ injection.

@article{Triggs1984InVL,
  title={In vivo lipid peroxidation in rat brain following intracortical Fe2+ injection.},
  author={William Triggs and Luther James Willmore},
  journal={Journal of neurochemistry},
  year={1984},
  volume={42 4},
  pages={976-80}
}
Cerebral contusion, cortical laceration, intracerebral hematoma formation, and hemorrhagic cortical infarction cause extravasation of red blood cells, followed by hemolysis, decompartmentalization of iron, formation and deposition of hemosiderin, and an increased incidence of epilepsy. In this experiment, 10 microliter of an aqueous solution containing 100 mmol/L FeCl2, 100 mmol/L CoCl2, or 0.9% (wt/vol) NaCl were injected at a depth of 1.8 mm into rat isocortex. The rate of formation of… CONTINUE READING