In vivo kinetics of magnetically targeted low-dose doxorubicin.

  title={In vivo kinetics of magnetically targeted low-dose doxorubicin.},
  author={A. Senyei and S. Reich and C. Gonczy and K. Widder},
  journal={Journal of pharmaceutical sciences},
  volume={70 4},
The in vivo kinetics of low-dose doxorubicin (0.05 mg/kg), entrapped in a carrier and magnetically targeted, were characterized in a rat tail model. Tissue concentrations of doxorubicin at a preselected target site and in various organs were followed over time. As late as 60 min postinjection, 3.7 microgram/g of drug was found at the target site with no detectable drug levels found in any organ. In comparison, a 100-fold higher dose (5.0 mg/kg iv) of free doxorubicin yielded drug concentrations… Expand
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