In vivo kinetics of magnetically targeted low-dose doxorubicin.

@article{Senyei1981InVK,
  title={In vivo kinetics of magnetically targeted low-dose doxorubicin.},
  author={A. Senyei and S. Reich and C. Gonczy and K. Widder},
  journal={Journal of pharmaceutical sciences},
  year={1981},
  volume={70 4},
  pages={
          389-91
        }
}
The in vivo kinetics of low-dose doxorubicin (0.05 mg/kg), entrapped in a carrier and magnetically targeted, were characterized in a rat tail model. Tissue concentrations of doxorubicin at a preselected target site and in various organs were followed over time. As late as 60 min postinjection, 3.7 microgram/g of drug was found at the target site with no detectable drug levels found in any organ. In comparison, a 100-fold higher dose (5.0 mg/kg iv) of free doxorubicin yielded drug concentrations… Expand
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References

SHOWING 1-7 OF 7 REFERENCES
Magnetic guidance of drug‐carrying microspheres
Physical laws underlying the intravascular magnetic guidance of a novel drug carrier are discussed. The drug carrier is a magnetically responsive drug‐bearing microsphere measuring approximately 1 μmExpand
Radioactive albumin microspheres for studies of the pulmonary circulation.
TLDR
The most common radiopharmaceutical for determining the distribution of pulmonary arterial blood flow is 131 -labeled macroaggregates of human serum albumin, but more recently both 113mIn-labeled floes of iron hydroxide and 99mTc- labeled MAA have also been used. Expand
Magnetic microspheres: synthesis of a novel parenteral drug carrier.
TLDR
The synthesis and characterization of a novel parenteral drug carrier capable of area specific localization by magnetic means and release doxorubicin was chemically identical to the starting material. Expand
Cytofluorescence localization of adriamycin and daunorubicin.
TLDR
The characteristic orange-red fluorescence of adriamycin or daunorubicin is easily detectable in tissues of drug-treated hamsters when examined by fluorescence microscopy, although some cytoplasmic drug fluorescence was detected in liver and kidney cells. Expand
Advances in pharmacology and chemotherapy
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.