In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects.

@article{Prager1986InVK,
  title={In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects.},
  author={Rudolf Prager and Penny Wallace and Jerrold M. Olefsky},
  journal={The Journal of clinical investigation},
  year={1986},
  volume={78 2},
  pages={472-81}
}
To determine whether abnormal kinetics of insulin's biologic actions contribute to the overall insulin resistance in obesity, we compared the rate of activation and deactivation of insulin's effects to stimulate glucose disposal rate (Rd) and inhibit hepatic glucose output (HGO) in 12 nonobese and 10 obese subjects using the euglycemic clamp technique at insulin infusion rates of 15, 40, 120, and 1,200 mU/M2 per min. In both groups, stimulation of Rd was faster the higher the insulin infusion… CONTINUE READING
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