In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection.

@article{Zhang2007InVK,
  title={In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection.},
  author={Yan Zhang and Diana L. Wallace and Catherine M de Lara and Hala Ghattas and Becca Asquith and Andrew T. Worth and George E. Griffin and Graham P Taylor and David F. Tough and Peter Beverley and Derek C. Macallan},
  journal={Immunology},
  year={2007},
  volume={121 2},
  pages={258-65}
}
Human natural killer (NK) cells form a circulating population in a state of dynamic homeostasis. We investigated NK cell homeostasis by labelling dividing cells in vivo using deuterium-enriched glucose in young and elderly healthy subjects and patients with viral infection. Following a 24-hr intravenous infusion of 6,6-D(2)-glucose, CD3(-) CD16(+) NK cells sorted from peripheral blood mononuclear cells (PBMC) by fluorescence-activated cell sorter (FACS) were analysed for DNA deuterium content… CONTINUE READING

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