In vivo kinetics of Cajal body components

  title={In vivo kinetics of Cajal body components},
  author={Miroslav Dundr and Michael D Hebert and Tatiana S. Karpova and David Staněk and Hongzi Xu and Karl B. Shpargel and U Thomas Meier and Karla M Neugebauer and A Gregory Matera and Tom Misteli},
  journal={The Journal of Cell Biology},
  pages={831 - 842}
Cajal bodies (CBs) are subnuclear domains implicated in small nuclear ribonucleoprotein (snRNP) biogenesis. In most cell types, CBs coincide with nuclear gems, which contain the survival of motor neurons (SMN) complex, an essential snRNP assembly factor. Here, we analyze the exchange kinetics of multiple components of CBs and gems in living cells using photobleaching microscopy. We demonstrate differences in dissociation kinetics of CB constituents and relate them to their functions. Coilin and… CONTINUE READING
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