In vivo kinetics of Cajal body components

@article{Dundr2004InVK,
  title={In vivo kinetics of Cajal body components},
  author={Miroslav Dundr and Michael D Hebert and Tatiana S. Karpova and David Staněk and Hongzi Xu and Karl B. Shpargel and U Thomas Meier and Karla M Neugebauer and A Gregory Matera and Tom Misteli},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={164},
  pages={831 - 842}
}
Cajal bodies (CBs) are subnuclear domains implicated in small nuclear ribonucleoprotein (snRNP) biogenesis. In most cell types, CBs coincide with nuclear gems, which contain the survival of motor neurons (SMN) complex, an essential snRNP assembly factor. Here, we analyze the exchange kinetics of multiple components of CBs and gems in living cells using photobleaching microscopy. We demonstrate differences in dissociation kinetics of CB constituents and relate them to their functions. Coilin and… CONTINUE READING
69 Citations
60 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 69 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 60 references

Mutational analysis of fibrillarin and its mobility in living human cells

  • D. Stanek, S. D. Rader, M. Klingauf, K. M. Neugebauer
  • J . Cell Biol .
  • 2003
Highly Influential
8 Excerpts

Similar Papers

Loading similar papers…