In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[11C]dimethyltryptamine

@article{Yanai2004InVK,
  title={In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[11C]dimethyltryptamine},
  author={Kazuhiko Yanai and Tatsuo Ido and Kiichi Ishiwata and Jun Hatazawa and Toshihiro Takahashi and Ren Iwata and Taiju Matsuzawa},
  journal={European Journal of Nuclear Medicine},
  year={2004},
  volume={12},
  pages={141-146}
}
The endogenous hallucinogen, N,N-dimethyltryptamine (DMT), was labeled with carbon-11 and its regional distribution in rat brain studied. [11C]DMT showed higher accumulation in the cerebral cortex, caudate putamen, and amygdaloid nuclei. Studies of the subcellular distribution of [11C]DMT revealed the specific localization in the fractions enriched with serotonin receptors only when a very low dose was injected into rats. The proportions of the radioactivity in receptor-rich fractions were… 

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