In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent

  title={In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent},
  author={Parjam S. Zolfaghari and Samantha Packer and Mervyn Singer and Sean P. Nair and Jon Bennett and Cale N Street and Michael Wilson},
  booktitle={BMC Microbiology},
The widespread problem of antibiotic resistance in pathogens such as Staphylococcus aureus has prompted the search for new antimicrobial approaches. In this study we report for the first time the use of a light-activated antimicrobial agent, methylene blue, to kill an epidemic methicillin-resistant Staphylococcus aureus (EMRSA-16) strain in two mouse wound models. Following irradiation of wounds with 360 J/cm2 of laser light (670 nm) in the presence of 100 μg/ml of methylene blue, a 25-fold… CONTINUE READING
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