In vivo interference of Rous sarcoma virus budding by cis expression of a WW domain.

@article{Patnaik2002InVI,
  title={In vivo interference of Rous sarcoma virus budding by cis expression of a WW domain.},
  author={Akash Patnaik and John W Wills},
  journal={Journal of virology},
  year={2002},
  volume={76 6},
  pages={2789-95}
}
For all enveloped viruses, the actual mechanism by which nascent virus particles separate or "pinch off" from the cell surface is largely unknown. In the case of retroviruses, the Gag protein drives the budding process, and the virus release step is directed by the late (L) assembly domain within Gag. A PPPPY motif within the L domain of Rous sarcoma virus (RSV) was previously characterized as being critical for the release of virions and shown to interact in vitro with the WW domain of Yes… CONTINUE READING