In vivo inhibition of foam cell development by probucol in Watanabe rabbits.

@article{Steinberg1988InVI,
  title={In vivo inhibition of foam cell development by probucol in Watanabe rabbits.},
  author={Daniel Steinberg and Sampath Parthasarathy and T E Carew},
  journal={The American journal of cardiology},
  year={1988},
  volume={62 3},
  pages={6B-12B}
}
Previous studies from this laboratory have shown that oxidative modification of low-density lipoprotein (LDL) causes it to be recognized by the scavenger receptor of the macrophage. Consequently, the rate of degradation of oxidized LDL by macrophages can be 3 to 10 times that of native LDL. Antioxidants, such as probucol, are highly effective in preventing… CONTINUE READING