In vivo inhibition of angiogenesis by a soluble form of melanotransferrin.

@article{MichaudLevesque2006InVI,
  title={In vivo inhibition of angiogenesis by a soluble form of melanotransferrin.},
  author={Jonathan Michaud-Levesque and Michel Demeule and Richard. Auteur du texte B{\'e}liveau},
  journal={Carcinogenesis},
  year={2006},
  volume={28 2},
  pages={
          280-8
        }
}
Melanotransferrin (MTf), the membrane-bound human melanoma antigen p97, binds to plasminogen and stimulates its activation, thus regulating a crucial step involved in angiogenesis. In our study, a truncated soluble form of MTf (sMTf) inhibits, in a dose-dependent manner, the in vitro tubulogenesis of human umbilical vessel endothelial cells (HUVEC) induced by media conditioned with MTf-expressing cells. Following these results, we used the in vivo Matrigel plug angiogenesis assay to investigate… CONTINUE READING

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