In vivo induction of pyrimidine dimers in human skin by UVA radiation: initiation of cell damage and/or intercellular communication?

@article{Applegate1999InVI,
  title={In vivo induction of pyrimidine dimers in human skin by UVA radiation: initiation of cell damage and/or intercellular communication?},
  author={Lee Ann Applegate and Corinne Scaletta and Renato G. Panizzon and Hugo J. Niggli and Edgar Frenk},
  journal={International journal of molecular medicine},
  year={1999},
  volume={3 5},
  pages={467-72}
}
Pyrimidine dimers participate as important factors in ultraviolet-induced lethality, mutagenicity and tumorgenicity. Substantial efforts have been made in recent years to understand the induction of pyrimidine photodimers and their repair in human skin cells exposed to low physiological fluences of UV-light. Dimers are known to be efficiently induced after UVC and UVB irradiation, but these photoproducts are also highly induced in DNA isolated from human skin irradiated with UVA. By using a… CONTINUE READING
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