In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2

@article{Kohsaka2007InVI,
  title={In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2},
  author={Hiroshi Kohsaka and Etsuko Takasu and Akinao Nose},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={179},
  pages={1289 - 1300}
}
Cell adhesion molecules (CAMs) are thought to mediate interactions between innervating axons and their targets. However, such interactions have not been directly observed in vivo. In this paper, we study the function and dynamics of Fasciclin2 (Fas2), a homophilic CAM expressed both pre- and postsynaptically during neuromuscular synapse formation in Drosophila melanogaster. We apply live imaging of functional fluorescent fusion proteins expressed in muscles and find that Fas2 and Discs-Large… CONTINUE READING
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