In vivo induction of insulin-like growth factor-I receptor and CD44v6 confers homing and adhesion to murine multiple myeloma cells.

@article{Asosingh2000InVI,
  title={In vivo induction of insulin-like growth factor-I receptor and CD44v6 confers homing and adhesion to murine multiple myeloma cells.},
  author={Kewal Asosingh and Ursula G{\"u}nthert and Marleen H C Bakkus and Hendrik De Raeve and Elles Goes and Ivan Van Riet and Ben Van Camp and Karin Vanderkerken},
  journal={Cancer research},
  year={2000},
  volume={60 11},
  pages={3096-104}
}
One of the main characteristics of multiple myeloma (MM) cells is their specific homing and growth in the bone marrow (BM). Differences between stroma-dependent and -independent MM cell lines may reveal key molecules that play important roles in their homing to the BM. We addressed this topic with a murine MM model, including the in vivo 5T33MM (5T33MMvv) stroma-dependent cell line and its in vitro stroma-independent variant (5T33MMvt). Fluorescence-activated cell-sorting analysis showed… CONTINUE READING

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