In vivo induction of heat shock proteins in the substantia nigra following L‐DOPA administration is associated with increased activity of mitochondrial complex I and nitrosative stress in rats: regulation by glutathione redox state

@article{Calabrese2007InVI,
  title={In vivo induction of heat shock proteins in the substantia nigra following L‐DOPA administration is associated with increased activity of mitochondrial complex I and nitrosative stress in rats: regulation by glutathione redox state},
  author={Vittorio Calabrese and Cesare Mancuso and Agrippino Ravagna and Marzia Perluigi and Chiara Cini and Carlo de Marco and D. Allan Butterfield and Anna Maria Giuffrida Stella},
  journal={Journal of Neurochemistry},
  year={2007},
  volume={101}
}
Increasing evidence suggests a critical role for oxidative and nitrosative stress in the pathogenesis of most important neurodegenerative disorders. Parkinson’s disease (PD) is a neurodegenerative disease characterized by a severe depletion in number of dopaminergic cells of the substantia nigra (SN). Administration of L‐DOPA (LD) is the more effective treatment for patients with PD. However, the vast majority of patients suffer LD‐related complications, which represent the major problem in the… Expand
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