In vivo induction of apoptosis by influenza virus.

@article{Mori1995InVI,
  title={In vivo induction of apoptosis by influenza virus.},
  author={I. Mori and T. Komatsu and K. Takeuchi and K. Nakakuki and M. Sudo and Y. Kimura},
  journal={The Journal of general virology},
  year={1995},
  volume={76 ( Pt 11)},
  pages={
          2869-73
        }
}
Intranasal exposure of mice to influenza virus led to cell death in bronchial/bronchiolar epithelial cells, alveolar cells and lymphoid cells. These cells displayed fragmentation of nuclei and chromatin condensation. Nick end-labelling of DNA in situ confirmed that such apoptotic cells had fragmented DNA. These results suggest that the influenza virus induces apoptosis in vivo. 
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These studies indicate that influenza A and B viruses induce apoptosis in cell cultures; thus, apoptosis may represent a general mechanism of cell death in hosts infected with influenza viruses. Expand
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It is suggested that influenza virus infection causes apoptotic death of cultured cells, and their fate might be determined at an early stage of the infection by induction of an apoptotic gene. Expand
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