In vivo increase in thrombin generation by four-factor prothrombin complex concentrate in apixaban-treated healthy volunteers.

@article{Cheung2015InVI,
  title={In vivo increase in thrombin generation by four-factor prothrombin complex concentrate in apixaban-treated healthy volunteers.},
  author={Y Whitney Cheung and Stefano Barco and Barbara A. Hutten and Joost C M Meijers and Saskia Middeldorp and Michiel Coppens},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2015},
  volume={13 10},
  pages={1799-805}
}
BACKGROUND Four-factor prothrombin complex concentrate (PCC) (Cofact; Sanquin Blood Supply) 50 IU kg(-1) increased thrombin generation beyond baseline values in healthy, rivaroxaban-treated subjects. OBJECTIVE To assess whether infusion with doses of 37.5 IU kg(-1) and 25 IU kg(-1) PCC reverses the anticoagulant effect of high-dose apixaban, another oral direct factor Xa inhibitor. METHODS In a randomized, double-blind, placebo-controlled, crossover study, six healthy subjects received… CONTINUE READING
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