In vivo-in vitro comparison of acute respiratory tract toxicity using human 3D airway epithelial models and human A549 and murine 3T3 monolayer cell systems.

@article{Sauer2013InVV,
  title={In vivo-in vitro comparison of acute respiratory tract toxicity using human 3D airway epithelial models and human A549 and murine 3T3 monolayer cell systems.},
  author={Ursula G. Sauer and Sandra Vogel and Annemarie Hess and Susanne Noreen Kolle and Lan Ma-Hock and Bennard van Ravenzwaay and Robert Landsiedel},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2013},
  volume={27 1},
  pages={
          174-90
        }
}
The usefulness of in vitro systems to predict acute inhalation toxicity was investigated. Nineteen substances were tested in three-dimensional human airway epithelial models, EpiAirway™ and MucilAir™, and in A549 and 3T3 monolayer cell cultures. IC(50) values were compared to rat four-hour LC(50) values classified according to EPA and GHS hazard categories. Best results were achieved with a prediction model distinguishing toxic from non-toxic substances, with satisfactory specificities and… CONTINUE READING
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