In vivo immune evasion mediated by the herpes simplex virus type 1 immunoglobulin G Fc receptor.

@article{Nagashunmugam1998InVI,
  title={In vivo immune evasion mediated by the herpes simplex virus type 1 immunoglobulin G Fc receptor.},
  author={Thandavarayan Nagashunmugam and J. Wagensbert Lubinski and Lemin Wang and L T Goldstein and Benjamin S. Weeks and Pavur R. Sundaresan and E H Kang and Glenn Dubin and Harvey M. Friedman},
  journal={Journal of virology},
  year={1998},
  volume={72 7},
  pages={
          5351-9
        }
}
Herpes simplex virus (HSV) glycoproteins gE and gI form an immunoglobulin G (IgG) Fc receptor (FcgammaR) that binds the Fc domain of human anti-HSV IgG and inhibits Fc-mediated immune functions in vitro. gE or gI deletion mutant viruses are avirulent, probably because gE and gI are also involved in cell-to-cell spread. In an effort to modify FcgammaR activity without affecting other gE functions, we constructed a mutant virus, NS-gE339, that has four amino acids inserted into gE within the… CONTINUE READING

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In Vivo Role of Complement-Interacting Domains of Herpes Simplex Virus Type 1 Glycoprotein Gc

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