In vivo imaging of therapy response to a novel Pan-HER antibody mixture using FDG and FLT positron emission tomography

@inproceedings{Nielsen2015InVI,
  title={In vivo imaging of therapy response to a novel Pan-HER antibody mixture using FDG and FLT positron emission tomography},
  author={Carsten Haagen Nielsen and Mette Munk Jensen and Lotte Kellemann Kristensen and Anna Dahlman and Camilla Fr{\"o}hlich and Helle Jane Jacobsen and Thomas Tuxen Poulsen and Johan Lantto and Ivan David Horak and Michael Kragh and Andreas Kjaer},
  booktitle={Oncotarget},
  year={2015}
}
PURPOSE Overexpression of the human epidermal growth factor receptor (HER) family and their ligands plays an important role in many cancers. Targeting multiple members of the HER family simultaneously may increase the therapeutic efficacy. Here, we report the ability to image the therapeutic response obtained by targeting HER family members individually or simultaneously using the novel monoclonal antibody (mAb) mixture Pan-HER. EXPERIMENTAL DESIGN AND RESULTS Mice with subcutaneous BxPC-3… CONTINUE READING
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