In vivo imaging of siRNA delivery and silencing in tumors

@article{Medarova2007InVI,
  title={In vivo imaging of siRNA delivery and silencing in tumors},
  author={Zdravka O Medarova and Wellington Pham and Christian T. Farrar and Victoria Petkova and Anna Moore},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={372-377}
}
With the increased potential of RNA interference (RNAi) as a therapeutic strategy, new noninvasive methods for detection of siRNA delivery and silencing are urgently needed. Here we describe the development of dual-purpose probes for in vivo transfer of siRNA and the simultaneous imaging of its accumulation in tumors by high-resolution magnetic resonance imaging (MRI) and near-infrared in vivo optical imaging (NIRF). These probes consisted of magnetic nanoparticles labeled with a near-infrared… CONTINUE READING

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