In vivo imaging of obesity-induced inflammation in adipose tissue.

  title={In vivo imaging of obesity-induced inflammation in adipose tissue.},
  author={Hiroshi Fushiki and Yoshihiro Hayakawa and Akira Gomori and Toru Seo and Shruti Tewari and Satoshi Ozaki and Ryo Yoshimoto},
  journal={Biochemical and biophysical research communications},
  volume={391 1},
Obesity is associated with low-grade inflammation in adipose tissue, which contributes to the development of obesity-related diseases such as insulin resistance, hypertension and arteriosclerosis. Here we developed an animal model that non-invasively monitors inflammation in adipose tissue using in vivo bioluminescent imaging (BLI) technique. In vitro, stimulation with TNFalpha or co-culture with RAW264 macrophages increased bioluminescence in 3T3-L1 adipocytes expressing NF-kappaB-mediated… CONTINUE READING

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