In vivo imaging of immune rejection in transplanted pancreatic islets.

@article{Evgenov2006InVI,
  title={In vivo imaging of immune rejection in transplanted pancreatic islets.},
  author={Natalia V. Evgenov and Zdravka O Medarova and John K Pratt and Pamela Pantazopoulos and Simone Leyting and Susan Bonner-Weir and Anna Moore},
  journal={Diabetes},
  year={2006},
  volume={55 9},
  pages={2419-28}
}
As islet transplantation becomes an acceptable clinical modality for restoring normoglycemia in type 1 diabetic patients, there is a crucial need for noninvasive assessment of the fate of the grafts. In spite of the success of the Edmonton Protocol, a significant graft loss occurs due to immunological and nonimmunological events immediately after transplantation. Allogeneic rejection in graft recipients is one of the major reasons for islet death and graft failure. Therefore, monitoring the… CONTINUE READING
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