In vivo imaging of human cholinergic nerve terminals with (-)-5-(18)F-fluoroethoxybenzovesamicol: biodistribution, dosimetry, and tracer kinetic analyses.

@article{Petrou2014InVI,
  title={In vivo imaging of human cholinergic nerve terminals with (-)-5-(18)F-fluoroethoxybenzovesamicol: biodistribution, dosimetry, and tracer kinetic analyses.},
  author={Myria Petrou and Kirk A. Frey and Michael R. Kilbourn and Peter J H Scott and David M Raffel and Nicolaas I. Bohnen and Martijn L. T. M. M{\"u}ller and Roger L Albin and Robert A. Koeppe},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2014},
  volume={55 3},
  pages={396-404}
}
UNLABELLED (-)-5-(18)F-fluoroethoxybenzovesamicol ((18)F-FEOBV) is a vesamicol derivative that binds selectively to the vesicular acetylcholine transporter (VAChT) and has been used in preclinical studies to quantify presynaptic cholinergic nerve terminals. This study presents, to our knowledge, the first-in-human experience with (18)F-FEOBV, including radiation dosimetry, biodistribution, tolerability and safety in human subjects, and brain kinetics and methods for quantitative analysis of (18… CONTINUE READING
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