In vivo imaging of human cerebral acetylcholinesterase.


We report here the first positron emission tomography (PET) images showing the in vivo regional distribution of acetylcholinesterase (AChE) in human brain. The study was carried out in eight healthy human volunteers using as a tracer [11C]-physostigmine ([11C]PHY), an inhibitor of AChE. After intravenous injection of [11C]PHY, radioactivity was rapidly… (More)


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@article{Pappat1996InVI, title={In vivo imaging of human cerebral acetylcholinesterase.}, author={Sabina Pappat{\`a} and Bertrand Tavitian and Latchezar Dintchov Traykov and Antoinette Jobert and A Dalger and J-F Mangin and Christian Crouzel and L DiGiamberardino}, journal={Journal of neurochemistry}, year={1996}, volume={67 2}, pages={876-9} }