In vivo imaging of cerebral serotonin transporter and serotonin(2A) receptor binding in 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") and hallucinogen users.

@article{Erritzoe2011InVI,
  title={In vivo imaging of cerebral serotonin transporter and serotonin(2A) receptor binding in 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") and hallucinogen users.},
  author={David Erritzoe and Vibe G. Frokjaer and Klaus K. Holst and M Christoffersen and Sys Stybe Johansen and Claus Svarer and Jacob Madsen and Peter M Rasmussen and Thomas Z. Rams\oy and Terry L. Jernigan and Gitte Moos Knudsen},
  journal={Archives of general psychiatry},
  year={2011},
  volume={68 6},
  pages={562-76}
}
CONTEXT Both hallucinogens and 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") have direct agonistic effects on postsynaptic serotonin(2A) receptors, the key site for hallucinogenic actions. In addition, MDMA is a potent releaser and reuptake inhibitor of presynaptic serotonin. OBJECTIVE To assess the differential effects of MDMA and hallucinogen use on cerebral serotonin transporter (SERT) and serotonin(2A) receptor binding. DESIGN A positron emission tomography study of 24 young… CONTINUE READING
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