In vivo imaging of cerebral microvascular plasticity from birth to death.

@article{Harb2013InVI,
  title={In vivo imaging of cerebral microvascular plasticity from birth to death.},
  author={Roa Harb and Christina Whiteus and Catarina Freitas and Jaime Grutzendler},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2013},
  volume={33 1},
  pages={146-56}
}
Cerebral function and viability are critically dependent on efficient delivery of oxygen and glucose through the microvasculature. Here, we studied individual microvessels in the intact brain using high-resolution confocal imaging and long-term time-lapse two-photon microscopy across the lifetime of a mouse. In the first postnatal month, we found large-scale sprouting but to our surprise the majority of sprouts underwent pruning and only a small fraction became perfused capillaries. After the… CONTINUE READING

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