In vivo imaging of cancer cell size and cellularity using temporal diffusion spectroscopy.

@article{Jiang2017InVI,
  title={In vivo imaging of cancer cell size and cellularity using temporal diffusion spectroscopy.},
  author={Xiaoyu Jiang and Hua Li and Jingping Xie and Eliot T. McKinley and Ping Zhao and John C. Gore and Junzhong Xu},
  journal={Magnetic resonance in medicine},
  year={2017},
  volume={78 1},
  pages={
          156-164
        }
}
PURPOSE A temporal diffusion MRI spectroscopy based approach has been developed to quantify cancer cell size and density in vivo. METHODS A novel imaging microstructural parameters using limited spectrally edited diffusion (IMPULSED) method selects a specific limited diffusion spectral window for an accurate quantification of cell sizes ranging from 10 to 20 μm in common solid tumors. In practice, it is achieved by a combination of a single long diffusion time pulsed gradient spin echo (PGSE… CONTINUE READING
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