In vivo imaging of breakdown of the inner and outer blood-retinal barriers.

@article{en1992InVI,
  title={In vivo imaging of breakdown of the inner and outer blood-retinal barriers.},
  author={Hasine Şen and Bruce A. Berkowitz and Noburo Ando and Eugene de Juan},
  journal={Investigative ophthalmology & visual science},
  year={1992},
  volume={33 13},
  pages={3507-12}
}
Real-time contrast-enhanced magnetic resonance imaging (MRI) was used to distinguish between experimentally induced breakdown of the vascular (inner) and retinal pigment epithelial (RPE; outer) blood-retinal barrier (BRB) in vivo. Pigmented rabbits were treated with intravenous sodium iodate 30 mg/kg, (a specific RPE cell poison), intravitreal N-ethylcarboxamidoadenosine (NECA) 10(-3) mol/l (which specifically disrupts the vascular BRB), or retinal diode laser photocoagulation. Coronal T1… CONTINUE READING
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