In vivo imaging of axonal degeneration and regeneration in the injured spinal cord

@article{Kerschensteiner2005InVI,
  title={In vivo imaging of axonal degeneration and regeneration in the injured spinal cord},
  author={Martin Kerschensteiner and Martin E. Schwab and Jeff William Lichtman and Thomas Misgeld},
  journal={Nature Medicine},
  year={2005},
  volume={11},
  pages={572-577}
}
The poor response of central axons to transection underlies the bleak prognosis following spinal cord injury. Here, we monitor individual fluorescent axons in the spinal cords of living transgenic mice over several days after spinal injury. We find that within 30 min after trauma, axons die back hundreds of micrometers. This acute form of axonal degeneration is similar in mechanism to the more delayed Wallerian degeneration of the disconnected distal axon, but acute degeneration affects the… 
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522 Citations
Highly Influential Citations
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Methods Citations
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522 Citations

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