In vivo human buccal permeability of nicotine.

  title={In vivo human buccal permeability of nicotine.},
  author={Charlotte L Adrian and Helle B D Olin and Kim Dalhoff and Jette H Jacobsen},
  journal={International journal of pharmaceutics},
  volume={311 1-2},
The aim was to examine the in vivo buccal pH-dependent permeability of nicotine in humans and furthermore compare the in vivo permeability of nicotine to previous in vitro permeability data. The buccal permeability of nicotine was examined in a three-way cross-over study in eight healthy non-smokers using a buccal perfusion cell. The disappearance of nicotine from perfusion solutions with pH 6.0, 7.4, and 8.1 was studied for 3h. The apparent permeability of nicotine (P(app)) was determined at… CONTINUE READING

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