In vivo high-frequency, contrast-enhanced ultrasonography of uveal melanoma in mice: imaging features and histopathologic correlations.

@article{Zhang2011InVH,
  title={In vivo high-frequency, contrast-enhanced ultrasonography of uveal melanoma in mice: imaging features and histopathologic correlations.},
  author={Qing Zhang and H Yang and Shin Jeong Kang and Yanggan Wang and Geoffrey D. Wang and Tonya Coulthard and Hans E. Grossniklaus},
  journal={Investigative ophthalmology & visual science},
  year={2011},
  volume={52 5},
  pages={2662-8}
}
PURPOSE To evaluate the usefulness of in vivo imaging of uveal melanoma in mice using high-frequency contrast-enhanced ultrasound (HF-CE-US) with 2D or 3D modes and to correlate the sonographic findings with histopathologic characteristics. METHODS Fourteen 12-week-old C57BL6 mice were inoculated into their right eyes with aliquots of 5 × 10(5)/2.5 μL B16LS9 melanoma cells and were randomly assigned to either of two groups. At 7 days after inoculation, tumor-bearing eyes in group 1 (n = 8… CONTINUE READING
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