In vivo hepatic and peripheral insulin resistance in genetically obese (fa/fa) rats.

@article{Terrettaz1983InVH,
  title={In vivo hepatic and peripheral insulin resistance in genetically obese (fa/fa) rats.},
  author={Johann Terrettaz and Bernard Jeanrenaud},
  journal={Endocrinology},
  year={1983},
  volume={112 4},
  pages={1346-51}
}
The techniques of hyperglycemic and euglycemic clamps previously used in human investigation have been adapted to small rodents to measure in vivo peripheral (muscle, adipose tissues) glucose metabolism and in vivo hepatic glucose production, in lean and genetically obese (fa/fa) rats. The aim of the study was 1) to assess the in vivo relevance of previously described in vitro abnormalities of muscle and adipose tissues producing insulin resistance in genetically obese (fa/fa) rats; 2) to… CONTINUE READING

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