In vivo hepatic adenoviral gene delivery occurs independently of the coxsackievirus-adenovirus receptor.

Abstract

Systemic administration of adenoviral vectors leads to a widespread distribution of vector. Therefore, targeting of adenoviral vectors to specific tissues or cell types will require methods to ablate the normal tropism of the vector simultaneously with the introduction of new receptor specificities. To inhibit native receptor binding, we mutated residues in… (More)

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