In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents.

@article{Schmittwolf2005InVH,
  title={In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents.},
  author={Carolin Schmittwolf and Nicole Kirchhof and Anna Jauch and Michael D{\"u}rr and Friedrich Harder and Martin Zenke and Albrecht M{\"u}ller},
  journal={The EMBO journal},
  year={2005},
  volume={24 3},
  pages={554-66}
}
Modifications of DNA and chromatin are fundamental for the establishment and maintenance of cell type-specific gene expression patterns that constitute cellular identities. To test whether the developmental potential of fetal brain-derived cells that form floating sphere colonies (neurospheres) can be modified by destabilizing their epigenotype, neurosphere cells were treated with chemical compounds that alter the acetylation and methylation patterns of chromatin and DNA. Intravenous infusion… CONTINUE READING

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