In vivo growth of a bioengineered internal anal sphincter: comparison of growth factors for optimization of growth and survival

@article{Miyasaka2010InVG,
  title={In vivo growth of a bioengineered internal anal sphincter: comparison of growth factors for optimization of growth and survival},
  author={Eiichi Miyasaka and Shreya Raghavan and Robert R. Gilmont and Krittika Mittal and Sita Somara and Khalil N. Bitar and Daniel Teitelbaum},
  journal={Pediatric Surgery International},
  year={2010},
  volume={27},
  pages={137-143}
}
Our laboratory has developed and implanted a novel bioengineered internal anal sphincter (IAS) to treat anal incontinence. Fibroblast growth factor-2 (FGF-2) has been used in mice; however, the optimal growth factor for successful IAS implantation is unclear. This study compares several growth factors in order to optimize IAS viability and functionality. Bioengineered IAS rings were implanted subcutaneously into the dorsum of wildtype C57Bl/6 mice, with an osmotic pump dispensing FGF-2… CONTINUE READING

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