In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats.

@article{Rossetti1995InVG,
  title={In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats.},
  author={Luciano Rossetti and Meredith Hawkins and Weina Chen and J J Gindi and Nir Barzilai},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={96 1},
  pages={132-40}
}
To test the hypothesis that increased flux through the hexosamine biosynthetic pathway can induce insulin resistance in skeletal muscle in vivo, we monitored glucose uptake, glycolysis, and glycogen synthesis during insulin clamp studies in 6-h fasted conscious rats in the presence of a sustained (7-h) increase in glucosamine (GlcN) availability. Euglycemic (approximately 7 mM) insulin (approximately 2,500 pM) clamps with saline or GlcN infusions were performed in control (CON; plasma glucose… CONTINUE READING

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Glucosamine and glucose induce insulin resistance by different mechanisms in rat skeletal muscle.

American journal of physiology. Endocrinology and metabolism • 2003
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