In vivo genotoxicity of sodium ortho-phenylphenol: phenylbenzoquinone is one of the DNA-binding metabolite(s) of sodium ortho-phenylphenol.

@article{Pathak1993InVG,
  title={In vivo genotoxicity of sodium ortho-phenylphenol: phenylbenzoquinone is one of the DNA-binding metabolite(s) of sodium ortho-phenylphenol.},
  author={Deena N. Pathak and Deodutta Roy},
  journal={Mutation research},
  year={1993},
  volume={286 2},
  pages={309-19}
}
We have previously demonstrated microsomal cytochromes P450-dependent redox cycling of o-phenylphenol and in vitro genotoxicity of o-phenylphenol. In the present work, we have investigated in vivo covalent modification in skin DNA by Na-o-phenylphenol using the 32P-postlabeling method in an attempt to understand the biochemical mechanism of promotion of chemical-induced skin carcinogenesis by Na-o-phenylphenol. Topical application of Na-o-phenylphenol or phenylhydroquinone, a hydroxylated… CONTINUE READING

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