In vivo genotoxicity assessment of sertraline by using alkaline comet assay and the cytokinesis-block micronucleus assay.

@article{Battal2013InVG,
  title={In vivo genotoxicity assessment of sertraline by using alkaline comet assay and the cytokinesis-block micronucleus assay.},
  author={Dīlek Battal and Ayça Aktaş and Mehmet Ali Sungur and Ela Kadioglu and Ebru Derici Eker and Nefise Ozlen Sahin and Sahan Saygi},
  journal={Basic & clinical pharmacology & toxicology},
  year={2013},
  volume={113 5},
  pages={339-46}
}
Sertraline, a leading antidepressant in the selective serotonin reuptake inhibitor (SSRI) group of medicine, is the most frequently prescribed drug. In this study, the alkaline comet assay and the cytokinesis-block micronucleus (CBMN) assay were used to investigate genotoxicity potential of sertraline in the peripheral blood lymphocytes (PBLs) of acute and chronic sertraline-treated Wistar albino rats. Male Wistar albino rats (n = 48) were administered low, medium and high doses of sertraline… CONTINUE READING
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