In vivo genotoxic effects of mercuric chloride in rat peripheral blood leucocytes using comet assay.

@article{Grover2001InVG,
  title={In vivo genotoxic effects of mercuric chloride in rat peripheral blood leucocytes using comet assay.},
  author={Paramjit Grover and B Saleha Banu and K. Dhanapati Devi and S. Begum},
  journal={Toxicology},
  year={2001},
  volume={167 3},
  pages={
          191-7
        }
}
DNA damage induced by Mercuric chloride (HgCl2) in leucocytes of Wistar albino male rats has been studied in vivo. The comet assay or the alkaline single cell gel electrophoresis (SCGE) assay was used to measure the DNA damage. The rats were administered orally with doses ranging from 0.0054, 0.0108, 0.0216, 0.0432 to 0.0864 mg/kg body weight (b.wt.) of HgCl2. The assay was performed on whole blood at 24, 48, 72 h, 1st and 2nd week. The reason leucocytes were used was to reflect biomarker… CONTINUE READING

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