In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene.

@article{Li1995InVG,
  title={In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene.},
  author={Jiwen Li and Bo Fang and Randy C. Eisensmith and Xiao Hong Li and Igor Nasonkin and Yen-chiu Lin-Lee and Martha P. Mims and Ana de S{\'a} Hughes and Craig Duvall Montgomery and John David Roberts},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={95 2},
  pages={
          768-73
        }
}
Elevations of plasma total or LDL cholesterol are major risk factors for cardiovascular disease. Efforts directed at preventing and treating cardiovascular disease have often focused on reducing the levels of these substances in the blood. The Watanabe Heritable Hyperlipidemic Rabbit, which has exceedingly high plasma cholesterol levels resulting from an LDL receptor deficiency, provides an excellent animal model for testing new treatments. A recombinant adenoviral vector containing the rabbit… CONTINUE READING

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