In vivo gene electroinjection and expression in rat liver.

@article{Heller1996InVG,
  title={In vivo gene electroinjection and expression in rat liver.},
  author={Richard Heller and Niraj Ramachandran and Andrew Atkin and Darius Moradpour and Ralph W. Gilbert and Jack R Wands and Claude S. Nicolau},
  journal={FEBS letters},
  year={1996},
  volume={389 3},
  pages={
          225-8
        }
}
In vivo targeted gene transfer by non-viral vectors is subjected to anatomical constraints depending on the route of administration. Transfection efficiency and gene expression in vivo using non-viral vectors is also relatively low. We report that in vivo electropermeabilization of the liver tissue of rats in the presence of genes encoding luciferase or beta-galactosidase resulted in the strong expression of these genetic markers in rat liver cells. About 30-40% of the rat liver cells… CONTINUE READING
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