In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate.

@article{Essalmani2008InVF,
  title={In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate.},
  author={Rachid Essalmani and Ahmed Zaid and Jadwiga Marcinkiewicz and Ann Chamberland and Antonella Pasquato and Nabil G Seidah and Annik Prat},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 15},
  pages={5750-5}
}
The proprotein convertase PC5/6 cleaves protein precursors after basic amino acids and is essential for implantation in CD1/129/Sv/C57BL/6 mixed-background mice. Conditional inactivation of Pcsk5 in the epiblast but not in the extraembryonic tissue bypassed early embryonic lethality but resulted in death at birth. PC5/6-deficient embryos exhibited Gdf11-related phenotypes such as altered anteroposterior patterning with extra vertebrae and lack of tail and kidney agenesis. They also exhibited… CONTINUE READING
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